Is there a big difference between a 22 (LR or Mag) and a 25 auto? I know the centerfire ammo is more reliable. Small 22 LR autos are easy to come by but how effective could one be if that was all a person had? I do know that 22 mags are one heck of a rimfire round but a person is limited to a revolver. Was just reading an article about mouseguns and got to wondering if a person had to choose between the three what would be best? I know there are many guns that are better for SD but thought this would make an interesting thread.