Coronavirus

[smokingman]

New study.Not peer reviewed,but as it is not breaking any new ground but looking at many other studies it still provides some decent findings.

Clinical, Laboratory and Imaging Features of COVID-19: A systematic review and meta-analysis
A total of 660 articles were retrieved using the search strategy, including 39 case reports. After screening by abstract and title,64 articles were selected for full-text assessment.

The mean age of patients across 18 studies was 51.97 years old (95%CI 46.06-57.89), being male 55.9% (95%CI 51.6-60.1%).Patients presented in 36.8% comorbidities (95%CI 24.7-48.9%), being the highest hypertension (18.6%, 95%CI 8.1-29.0%),cardiovascular disease (14.4%, 95%CI 5.7-23.1%), and diabetes (11.9%, 95%CI 9.1-14.6%)

Regarding the clinical manifestations, fever (88.7%, 95%CI 84.5-92.9%), cough (57.6%, 40.8-74.4%) and dyspnea( difficult or labored breathing)(45.6%)

Among the patients, 20.3% (95%CI 10.0-30.6%) required ICU, with 32.8% presenting ARDS (95%CI 13.7-51.8), 13.0%acute cardiac injury (95%CI 4.1-21.9%), 7.9% acute kidney injury (95%CI 1.8-14.0%), 6.2% (95%CI 3.1-9.3%) with shockand with a fatal outcome in 13.9% (95%CI 6.2-21.5%) (Table 6). RNAemia was reported 96.8% of the patients (95%CI 94.9-diarrhea is reported in 20-25% of patients(<---I had not seen this in a clinical case study yet)



More at the source.

https://www.preprints.org/manuscript/202002.0378/v2

 

[smokingman]

The world case count doubling overnight?

After days of denial and downplaying the Coronavirus outbreak in Iran, the regime’s Deputy Health Minister GhasemJanbabaei admitted in an interview on state TV that “over 12,000 people have been hospitalized after being diagnosed with the coronavirus and this is only 20 percent of the individuals who have tested positive for the COVID-19 virus.”

https://www.ncr-iran.org/en/news/so...ted-over-650-dead-yet-no-action-by-the-regime

I am also looking for another source to confirm this.It is hard to search in other languages.

 

[ditcherman]

If you read one post in this thread, read this one. This is circulating on Facebook:

Useful tips to avoid any kind of transmissible illness


Attributed to James Robb, a pathologist formerly at UC San Diego.


Subject: What I am doing for the upcoming COVID-19 (coronavirus) pandemic


Dear Colleagues,


As some of you may recall, when I was a professor of pathology at the University of California San Diego, I was one of the first molecular virologists in the world to work on coronaviruses (the 1970s). I was the first to demonstrate the number of genes the virus contained. Since then, I have kept up with the coronavirus field and its multiple clinical transfers into the human population (e.g., SARS, MERS), from different animal sources.


The current projections for its expansion in the US are only probable, due to continued insufficient worldwide data, but it is most likely to be widespread in the US by mid to late March and April.


Here is what I have done and the precautions that I take and will take. These are the same precautions I currently use during our influenza seasons, except for the mask and gloves.:


1) NO HANDSHAKING! Use a fist bump, slight bow, elbow bump, etc.


2) Use ONLY your knuckle to touch light switches. elevator buttons, etc.. Lift the gasoline dispenser with a paper towel or use a disposable glove.


3) Open doors with your closed fist or hip - do not grasp the handle with your hand, unless there is no other way to open the door. Especially important on bathroom and post office/commercial doors.


4) Use disinfectant wipes at the stores when they are available, including wiping the handle and child seat in grocery carts.


5) Wash your hands with soap for 10-20 seconds and/or use a greater than 60% alcohol-based hand sanitizer whenever you return home from ANY activity that involves locations where other people have been.


6) Keep a bottle of sanitizer available at each of your home's entrances. AND in your car for use after getting gas or touching other contaminated objects when you can't immediately wash your hands.


7) If possible, cough or sneeze into a disposable tissue and discard. Use your elbow only if you have to. The clothing on your elbow will contain infectious virus that can be passed on for up to a week or more!


What I have stocked in preparation for the pandemic spread to the US:
1) Latex or nitrile latex disposable gloves for use when going shopping, using the gasoline pump, and all other outside activity when you come in contact with contaminated areas.
Note: This virus is spread in large droplets by coughing and sneezing. This means that the air will not infect you! BUT all the surfaces where these droplets land are infectious for about a week on average - everything that is associated with infected people will be contaminated and potentially infectious. The virus is on surfaces and you will not be infected unless your unprotected face is directly coughed or sneezed upon. This virus only has cell receptors for lung cells (it only infects your lungs) The only way for the virus to infect you is through your nose or mouth via your hands or an infected cough or sneeze onto or into your nose or mouth.


2) Stock up now with disposable surgical masks and use them to prevent you from touching your nose and/or mouth (We touch our nose/mouth 90X/day without knowing it!). This is the only way this virus can infect you - it is lung-specific. The mask will not prevent the virus in a direct sneeze from getting into your nose or mouth - it is only to keep you from touching your nose or mouth.


3) Stock up now with hand sanitizers and latex/nitrile gloves (get the appropriate sizes for your family). The hand sanitizers must be alcohol-based and greater than 60% alcohol to be effective.


4) Stock up now with zinc lozenges. These lozenges have been proven to be effective in blocking coronavirus (and most other viruses) from multiplying in your throat and nasopharynx. Use as directed several times each day when you begin to feel ANY "cold-like" symptoms beginning. It is best to lie down and let the lozenge dissolve in the back of your throat and nasopharynx. Cold-Eeze lozenges is one brand available, but there are other brands available.


I, as many others do, hope that this pandemic will be reasonably contained, BUT I personally do not think it will be. Humans have never seen this snake-associated virus before and have no internal defense against it. Tremendous worldwide efforts are being made to understand the molecular and clinical virology of this virus. Unbelievable molecular knowledge about the genomics, structure, and virulence of this virus has already been achieved. BUT, there will be NO drugs or vaccines available this year to protect us or limit the infection within us. Only symptomatic support is available.
I hope these personal thoughts will be helpful during this potentially catastrophic pandemic. You are welcome to share this email. Good luck to all of us!


Jim
James Robb, MD FCAP

He's denying transmission through air, which I thought was still up for grabs. I think I've heard it called 'aerosolized"?

Never heard it called snake associated before. Definitely appeals to my religious senses.

Many important points!

 

[tbhausen]

He's denying transmission through air, which I thought was still up for grabs. I think I've heard it called 'aerosolized"?

Never heard it called snake associated before. Definitely appeals to my religious senses.

Many important points!

Yeah, the snake associated part caught my attention, too.

 

[Phase2]

I'd say correct, but very incomplete.

First: It isn't the only cost: Cooperation in exercising "best practices" to limit spread and minimize effect is impossible in an environment of #resist. Ex: Minimizing cross-border travel.
Second: Locked in positions also leads to politicizing disease. Ex: #resist led to calling Trump racist for shutting down travel to/from China. Conversely, it is doubtful that theoretical Democrat Hillary would have taken a similar measure.

 

[T.Lex]

The blood-brain-barrier information is interesting. There's alot we don't know about that, physiologically. There are other infectious materials that we're still learning about that can cross.

The net of it is, though, that it is a disturbing clinical development.

ETA:
Also, the diabetes as a risk factor is... uncommon? I mean, I'm not a virologist (obviously), but I don't recall any other of these pandemic-ish things having a morbidity link with diabetes.

 

[Trigger Time]

The blood-brain-barrier information is interesting. There's alot we don't know about that, physiologically. There are other infectious materials that we're still learning about that can cross.

The net of it is, though, that it is a disturbing clinical development.

ETA:
Also, the diabetes as a risk factor is... uncommon? I mean, I'm not a virologist (obviously), but I don't recall any other of these pandemic-ish things having a morbidity link with diabetes.

Diabetes makes you have a higher risk of dying from everything.
I have it. Doctor tells me about it all the time. I've worked really hard since being diagnosed to get it under control.

 

[T.Lex]

Diabetes makes you have a higher risk of dying from everything.
I have it. Doctor tells me about it all the time. I've worked really hard since being diagnosed to get it under control.

Yeah, I get that.

I just don't recall any of the previous infectious pandemic rehearsals having a clinical emphasis on it. Faulty memory, not important back then, probably an issue on my side of the analysis.

 

[Trigger Time]

Yeah, I get that.

I just don't recall any of the previous infectious pandemic rehearsals having a clinical emphasis on it. Faulty memory, not important back then, probably an issue on my side of the analysis.

Yeah maybe not. I haven't really ready up on many previous ones like I have this one. I just know the diabetus is a succubus.

 

[Phase2]

Ummm... Wow.

Iranian coronavirus count jumps 50% in one day. Well, maybe they are just doing a better job at identifying it...

Or maybe not...

Iranians have posted several videos on social media, featuring devout Shi’ites licking holy shrines in defiance of the coronavirus.

I'd have to say that I wouldn't be surprised if more of their senior leadership succumbs if they practice their faith this way.

Edit:
I'm not aware of any other country having such a problem specifically with legislators and other national leaders.
Coronavirus Infects 23 Iranian Lawmakers As Ayatollah Orders Military to Help Fight Spread

 

[T.Lex]

Insha'allah.

 

[dusty88]

The blood-brain-barrier information is interesting. There's alot we don't know about that, physiologically. There are other infectious materials that we're still learning about that can cross.

The net of it is, though, that it is a disturbing clinical development.

ETA:
Also, the diabetes as a risk factor is... uncommon? I mean, I'm not a virologist (obviously), but I don't recall any other of these pandemic-ish things having a morbidity link with diabetes.

"Risk factor" from the epidemiologic standpoint may not mean what you think it means .

Risk factors are correlations, not necessarily causations.

It's a good bet that a certain % of diabetics are older, overweight people with secondary heart disease as well. So they may fall into the higher risk camp.

The example I often use is a bit morbid but hits the point. If you looked at risk factors for suicide, you would likely see Iphone ownership as a risk factor. That doesn't mean the Iphone contributes to suicide moreso than Android. Teenagers (as we all know) are a group at higher risk for suicide. Teenager are more likely to own Iphones.

Soooo... while diabetes is troublesome for any disease (trying to manage blood sugar when you are having appetite or metabolic problems) it may not be a strong causative link with mortality in this illness. It may just be that a certain % of the diabetics have that causative link and take the averages up.

 

[T.Lex]

"Risk factor" from the epidemiologic standpoint may not mean what you think it means .

Risk factors are correlations, not necessarily causations.

It's a good bet that a certain % of diabetics are older, overweight people with secondary heart disease as well. So they may fall into the higher risk camp.

The example I often use is a bit morbid but hits the point. If you looked at risk factors for suicide, you would likely see Iphone ownership as a risk factor. That doesn't mean the Iphone contributes to suicide moreso than Android. Teenagers (as we all know) are a group at higher risk for suicide. Teenager are more likely to own Iphones.

Soooo... while diabetes is troublesome for any disease (trying to manage blood sugar when you are having appetite or metabolic problems) it may not be a strong causative link with mortality in this illness. It may just be that a certain % of the diabetics have that causative link and take the averages up.

Yeah, I understand correlation does not mean causation.

I just don't remember even a prior correlation with these kinds of things. Maybe it is just implicit, in the sense that everyone knows diabetes complicates almost every kind of malady.

 

[dusty88]

Yeah, I understand correlation does not mean causation.

I just don't remember even a prior correlation with these kinds of things. Maybe it is just implicit, in the sense that everyone knows diabetes complicates almost every kind of malady.

Or it may not be the diabetes directly. It may be that group has a high overlap with other conditions that increase the susceptibility.

 

[Cameramonkey]

Ummm... Wow.

Iranian coronavirus count jumps 50% in one day. Well, maybe they are just doing a better job at identifying it...

Or maybe not...


I'd have to say that I wouldn't be surprised if more of their senior leadership succumbs if they practice their faith this way.

Edit:
I'm not aware of any other country having such a problem specifically with legislators and other national leaders.
Coronavirus Infects 23 Iranian Lawmakers As Ayatollah Orders Military to Help Fight Spread

And you could probably say that maybe they are practicing the wrong faith? (or the right faith in the wrong ways)

 

[BugI02]

Yeah, I understand correlation does not mean causation.

I just don't remember even a prior correlation with these kinds of things. Maybe it is just implicit, in the sense that everyone knows diabetes complicates almost every kind of malady.

Both Type 1 and Type 2 cause renal damage/complications and Covid19 has a known predilection for small tubules in kidneys. Perhaps attack on already compromised kidneys leads to renal failure

 

[smokingman]

[h=1]India Restricts Exports of Common Drugs on Fear of Coronavirus Shortages[/h]The drugs include over-the-counter painkiller and fever reducer paracetamol and finished pills that include it. Similar export restrictions have been placed on the common antibiotic metronidazole, various versions of vitamin B and eight other medicinal chemicals, according to a notice from the Indian government Tuesday.


“India has restricted the export of 26 active pharmaceutical ingredients for export, which represents about 10% of their export capacity,” U.S. Food and Drug Administration Commissioner Stephen Hahn told Congress at a hearing Tuesday in Washington.

https://www.bloomberg.com/news/arti...nt=business&cmpid=socialflow-twitter-business

 

[ultra...good]

Well, isn't this nice:

"Far-left Denver City Democrat Councilwoman Candi CdeBaca stated from her government Twitter account on Monday that she stands in “solidarity” with someone who posted a graphic stating that if they became infected with the coronavirus, they wanted to attend as many Trump rallies as possible in an apparent effort to infect supporters of President Donald Trump.

CdeBaca, who has advocated for communism in the past, responded to a tweet that featured a graphic that stated: “For the record, if I do get the coronavirus I’m attending every MAGA rally I can.”"
https://www.dailywire.com/news/denve...mp-supporters/

 

[smokingman]

[h=2]The second case in New York raises the prospect of the virus spreading locally.[/h]
GGov. Andrew M. Cuomo announced on Tuesday morning a second confirmed case of the coronavirus in New York, saying that a man in his 50s in Westchester County, just outside of New York City, had tested positive.
The patient had no history of recent travel to any known places where the virus is spreading and had not come into contact with other infected people, suggesting that the pathogen is spreading locally.
The patient, whose test was confirmed overnight in New York City, is a lawyer who works in Manhattan and lives in New Rochelle
https://www.nytimes.com/2020/03/03/world/coronavirus-news.html

 

[jedi]

This is how they think.
Are you suprised?
If ya r gonna die, might as well take the enemy out as well is their logic.