Is the 22 TCM as fussy about how it's reloaded as the 5.7x28? I'm guessing that since it is mostly fired from a 1911 or a rifle it's not as touchy?
A 9mm necked down to shoot .224" bullets...stranger things have happened, I guess.
Traditionally, if you wanted more from a pistol, you went up in caliber and dealt with the recoil. I guess I don't see the draw of a round like this, other than it is "different". I have a couple of 22 rimfire pistols that I enjoy shooting and plinking with, but for the most part, 35 caliber is about as small as I'll go for a pistol.