Hs6 is my go to powder for middle of the road loads.I shoot cast 210 gr to 250 gr. Do't know about speed, just don't want to shoot a round that hurts anymore. Been using 8 gr of Unique.
You should try 300MP. Greencastle has it.If I want to be polite - 8.0gns of CFE pistol under a 215gn Trooper cast. Nice plinking load. More of a 44 special +P.
For full house - 21.8gns of H110 under a 210 XTP. That will hammer some steel. It's unpleasantly stout in a model 57 and shoots really well from a Henry 41 Mag lever.
H110 is not temperature stable though, so it really pushes back on hot days.