Good point . . . If the firing pin and path are getting gritty, that may cause enough reduction in force that the round will not fire. I'll take the gun apart tonight and investigate further.Most 22 handguns are a bit pinicky.
American Eagle doesn't seem to work in most of my pistols.
Try giving the pistol a good cleaning. And lubrication.
Pay attention to the striker, and its path.
Bring a coupole, or 3 boxes of different ammo.