I've got both calibres and like them both, but I flat out love my .357's. Got one in a Taurus and one in a S&W. I like carrying the .357 S&W, but the .45 Taurus Mil-Pro is my usual EDC. If I had to pick one to carry, to the exclusion of the others it would be the .357, hand down. It's just the best of the best, IMO.