Nope, the grip screws are fine, and my two-piece guide rod has never come loose. I did read about putting some JW Weld on the threads to keep it from coming apart, but I have never had an issue. I don't want to take it apart to glue it in case that makes it easier to come apart. As long as it is holding, I leave it alone.
You would think some aftermarket company would come out with a single-piece guide rod if that was such a big issue, but I have not seen anything out there.
I do check mine whenever I strip and clean the gun however.
This is good to hear although it appears as more than a few have experienced these kind of problems. I don't think I would be so concerned if it weren't for som reporting issues with stripped screw holes. I guess I find the whole two piece guide rod thing just a bit odd to say the least.