The one negative side to the Spydercos is that crap clip attachments. The screws will loosen quick over time.
Just to add another data point to the discussion...the clip screws on my multiple Spydercos have held strong for years and years with NO loosening whatsoever. Same story for all my Benchmade knives.
As with any screw fastener that refuses to stay tight, an appropriate amount of loctite usually resolves the issue. For these particularly small screws, I'd use blue 222 (purple)...but I highly doubt you'll need it, especially if you don't remove the clip from the factory position.