Depends on what you consider "a lot" and the age of the truck. For my truck, a 2012, per Edmunds it's about a $1k difference.
Maybe it's just the availability that's the big deal? I wonder if a lot of the highly priced used pickup's are because the owners are still making payments and having a balance? How long are they extending vehicle loans for now days?
Is the pickup market affected like the modern car market, with leasing as the current snake oil?