There is no reason to set up a dedicated home defense rifle at 50 yards.
But what if you have a really big open house?
I have my laser and RDS sighted in for close range. I did have the laser (green) set up for really close, in the house range. I changed it out with a laser/light combo and have it set to the red dot right now.
Makes me think that having two different POI on the same gun might give too much margin for error.