I know enough about reloading to get into trouble, but I would start with changing the powder. Have you ever tried Clay? If I'm totally off base let me know.
I bet you're burning dirty.
Try a bit more crimp. 1/4 turn at a time.
Josh
in .45 auto you should be "crimping" just to remove the bell from the powder funnel, not to squeeze the bullet more. I would be more concerned about crimp consistancy, not so much amount of crimp. If you are equating crimp to initial pressure, I'd start looking at oal.
not sure what you mean by burning dirty... if implying not all powder getting burnt, then there are other problems besides crimp.... powder too slow for application, charge needs adjusting, oal needs adjusting, etc.
-rvb