My EDC - XDm 3.8 compact 9mm loaded with Federal HST 124grain +P. One in chamber and 11 in magazine. I leave it sitting on the dresser about 6 feet from where I sleep. I also have a full size XDm 9mm - but that one is in a small Sentry safe in the closet a little further away.
G23 with one in the chamber with a full mag of JHP and a G19 5ft away with a full mag of JHP. And when I am not at home the 23 is with me and the 19 stays home with the wife.
Nightstand duty is covered by a Sig Scorpion full size 1911 with a light on the rail. I also usually put my Sig P238 on the nightstand as well. A Mossberg 500 is within arms reach. I love being able to look at the nightstand in the dark and see all of those tritium sights looking back.